Malaria Rdts

Jon Dec MDL 252 Fall 2011

RDTs

As with most parasitic infestations that atomic number 18 caused by protozoa, the immune system often controls the degree of which the infestation weed progress. Since the parasite that causes malaria targets the intracellular portion of the Erythrocyte, the PB derogate has been the standard method used for diagnosis. Immunochromatographic test technology is base on the ability to isolate the parasite antigen clear the blood. As we have learned the blood contains antibodies in either a monoclonal or polyclonal form. These antibodies ar specific for antigens that the protozoa form and thereby can be used against these specifically.

As the closing off of various proteins and enzymes produced in the various stages of infection progressed, RDTs were actual using immunogenitic compounds. These compounds were derivitized and used in a separation proficiency using a mobile phase and a unmoving phase, labeled chromatography. These tests were called immunochromatographic tests and were specific for the detection of malaria antigens. Currently, these tests can target the histidine-rich protein 2 of P. falciparum, a pan-malarial Plasmodium aldolase, and the parasite specific lactate dehydrogenase.



These tests are unique in the fact that they do not read a formal laboratory, electricity, or instrumentation. To date the person runway these tests do not require special training. For this discussion we testament review three tests all which are immunochromatographic but expend different proteins, enzymes and physical detection systems. The first test was veritable by isolating, Histidine a protein of P. falciparum (PfHRP2), a water soluble protein that is produced by the gametocytes of Plasmodium. Falciparume,

Histidine locates itself on the surface of the red blood cell and can be detected a month after antigen presentation. It is too detectable for thirty days after treatment has started.

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